Over the past few decades, the amorphous solid dispersions (ASDs) technique has emerged\nas a promising strategy to enhance the in vitro/in vivo characteristic of hydrophobic drugs. The low\naqueous solubility and poor bioavailability of atorvastatin calcium (ATO), a lipid-lowering drug,\npresent challenges for effective drug delivery. The objective of this work was to improve the\naqueous solubility, in vitro dissolution, and oral absorption of ATO with amorphous solid dispersion\ntechnique prepared by spray-drying method. The optimized ternary formulation comprising of\nATO; hydroxypropyl methylcellulose (HPMC), as a hydrophilic polymer; and sodium lauryl sulfate\n(SLS), as a surfactant, at a weight ratio of 1/1/0.1, showed significant improvement in aqueous\nsolubility by�����.
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